Current synthetic methods for wound repair do not fully address patient needs, as they are unable to mimic real human skin and don’t offer a functional, customizable scaffold that can adapt to specific pathologies. On the experimental side, skin models lack an active dermal matrix with fibroblasts to produce and modulate functional extracellular matrix components. To address both needs, our product will consist in a bi-layer, acellular, animal–free biomaterial with optimized biomechanical properties


The biomaterial proposed in the TISSYOU project is a new product in the field of ultra-equivalent skin substitutes.

Our product consists of an anatomo-mimetic bilayer matrix which exhibits optimized biomechanical properties mimicking human skin. The architecture of our biomaterial includes both a dermal and an epidermal layer in one product able to activate cutaneous cells, either cultured in-vitro or recruited in-vivo. The ultra-equivalence of our biomaterial will improve cell function and full-thickness skin reconstruction as well as wound healing in-vivo. Furthermore, our biomaterial is free of animal products, being fully synthetic.